Multiple Cytokine mRNA Expression in Human Mast Cells Stimulated via FcεRI
نویسندگان
چکیده
منابع مشابه
FcεRI expression and dynamics on mast cells.
Mast cells are key effector and immunoregulatory cells in IgE-associated immune responses, including allergic disorders. IgE antibodies bind to the high-affinity IgE receptor, FcεRI, expressed on the surface of mast cells; antigen-induced cross-linking of FcεRI-bound IgE molecules activates the mast cell to release an array of proinflammatory and immunomodulatory mediators. Because mast cells o...
متن کاملNotch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms.
Th2-type cytokines and TNF-α secreted by activated mast cells upon cross-linking of FcεRI contribute to the development and maintenance of Th2 immunity to parasites and allergens. We have previously shown that cytokine secretion by mouse mast cells is enhanced by signaling through Notch receptors. In this study, we investigated the molecular mechanisms by which Notch signaling enhances mast cel...
متن کاملEXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS
Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...
متن کاملRoles of RabGEF1/Rabex-5 domains in regulating FcεRI surface expression and FcεRI-dependent responses in mast cells
165 words Text: 4999 words Running title: Role of RabGEF1 Vps9 domain in cell activation Category: Immunobiology Corresponding Author: Stephen J. Galli Department of Pathology, Stanford University School of Medicine, Stanford, CA 943055324, USA [email protected] Phone: (650) 723-7975 Fax: (650) 725-6902 Blood First Edition Paper, prepublished online March 6, 2007; DOI 10.1182/blood-2007-01-06...
متن کاملfcεri-α sirna inhibits the antigen-induced activation of mast cells
fcεri, the high affinity receptor for ige plays a critical role in triggering the allergic reactions. it is responsible for inducing mast cell degranulation and deliberation of allergy mediators when it is aggregated by allergen and ige complexes. fcεri on the mast cells consists of three subunits; α chain directly binds ige, β chain and dimmer of γ chains together mediate intracellular signali...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 1995
ISSN: 1018-2438,1423-0097
DOI: 10.1159/000236963